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Patients with early disease did not receive concomitant levodopa therapy during treatment with pramipexole; those with advanced Parkinson's disease all received concomitant levodopa treatment.

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The reason this is unlikely to work for PSP is that while in Parkinson's, most of the movement problem is caused by loss of the main dopamine-producing nucleus, the substantia nigra, while in PSP, the movement problems are caused by loss of many other nuclei in addition.

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Approximately 12% of 260 patients with advanced Parkinson's disease who received MIRAPEX tablets and concomitant levodopa in the double-blind, placebo-controlled trials discontinued treatment due to adverse reactions compared with 16% of 264 patients who received placebo and concomitant levodopa.

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